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What structure holds together the pentamerform of IgM?

  1. Disulfide bonds

  2. Peptide bonds

  3. "J-chain"

  4. Hydrogen bonds

The correct answer is: "J-chain"

The pentameric form of Immunoglobulin M (IgM) is specifically associated with a structural component known as the J-chain. This J-chain is a polypeptide that facilitates the polymerization of five IgM monomers, resulting in the larger pentameric structure. The J-chain plays a critical role in stabilizing this form of IgM, allowing it to function effectively in immune responses. While disulfide bonds, peptide bonds, and hydrogen bonds are present within the overall structure of antibodies and play important roles in maintaining their stability and functionality, it is the J-chain that is essential for linking the individual IgM monomers together into the pentameric form. The presence of the J-chain is crucial for the biological activities of IgM, including its ability to effectively agglutinate pathogens and activate complement pathways.